The nucleophilic syntheses which were developed recently are able to provide F-DOPA by automated syntheses in very high specific activities, radiochemical yields, and enantiomeric purities. Among these, the no-carrier-added nucleophilic introduction of fluorine-18, especially, has gained increasing attention as it gives F-DOPA in higher specific activities and shorter reaction times by less intricate synthesis protocols. With the application of this tracer in neuroendocrine tumor imaging, improved radiosyntheses have been developed. Recent findings however point to very favorable results of this tracer for the imaging of other malignant diseases such as neuroendocrine tumors, pheochromocytoma, and pancreatic adenocarcinoma expanding its application spectrum. For many years, the main application of F-DOPA has been the PET imaging of neuropsychiatric diseases, movement disorders, and brain malignancies.
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